Bevacuzimab May Be Less Effective in Obese Metastatic Colorectal Cancer Patients

Obesity is a well-known carcinogenic factor for colorectal cancer [1, 2]. However, the relationship between obesity and malignancy is still not well understood. Obesity can cause production of VEGF, angiopoietin-2, and other growth factors that induce tumor growth [3, 4]. It can also cause insulin resistance, hyperinsulinemia, and increased production of adipokines and proinflamatory cytokines that may be associated
with tumor progression [5]. A recent study suggested a link between obesity and sporadic MSI-high colorectal cancer in women [6]. …